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ADDITION (Anglo-Danish-Dutch Study of Intensive Treatment and Complication Prevention in Type 2 Diabetic Patients Identified by Screening in Primary Care)

Diabetes is a common chronic condition associated with risk of heart disease, eye and kidney damage. Early detection of diabetes may result in health benefits, but this is not proven. The ADDITION study aims to test whether screening for diabetes is feasible, particularly within a South Asian population, and to measure the benefits of early detection and intensive treatment. In short a randomised controlled trial of the cost effectiveness of a screening and intensive multi-factorial intervention programme for Type 2 diabetes mellitus.

The Leicester ADDITION study is providing a cohort of diabetes patients for the ADDITION Europe Study which will run for 5 years. Countries participating in ADDITION Europe include the UK (Leicester and Cambridge), Denmark and the Netherlands. Once patients are diagnosed with diabetes they have the option to enter the intervention part of the study which follows their care for the 5 years. Patients are randomised to receive either routine GP care or an intensive care programme based at UHL. We currently have 79 intensive patients and 123 routine patients.


What is the purpose of the study?


Type 2 diabetes is a disease where blood sugar levels (glucose) in the body become uncontrolled due to the pancreas not producing enough insulin and the body not responding to the insulin effectively.


Patients who are diagnosed with Type 2 diabetes are at risk of suffering with problems associated with the feet, eyes, heart, circulation and kidneysPast research has shown that a lot of people have type 2 diabetes without knowing that they have the disease.
Rising Epidemic- facts and figures in Leicestershire


Whilst type 2 diabetes is untreated damage may be being caused to the, eyes, heart and feet and other organs, because of this the health care agencies are looking at the prevention and early detection of type 2 diabetes, in people who are at risk of developing the disease. The aim of screening people for diabetes is to pick up early signs of type 2 diabetes mellitus and therefore help control the disease to avoid some of the problems, which can arise from having the condition.


Although it seems sensible to think that screening people and detecting diabetes would be beneficial, there is no evidence to prove that this is better in the long term. The main aim of this study is to find out, over the next five years, whether detecting diabetes through screening and starting treatment earlier can reduce the risk of complications of diabetes such as heart attacks. This study will last for 5 years. This study will involve being screened for diabetes and then followed up if you are diagnosed with diabetes.

We will also find some people who have pre-diabetes. This is a condition where the levels of sugar in the blood are too high to be classed as normal but too low to be classed as diabetes. We know that 50% people with pre-diabetes will go on to get diabetes within 10 years, however the chance of getting diabetes can be dramatically reduced with small changes to lifestyle.


How do I get involved?


The only way to get involved in this study is: